In 1835 he carried out excavations at the pyramids of Giza, which were considered to be one of the most important investigations on this area to have been carried out during the nineteenth century.
Vyse subsequently wrote Operations carried on at the pyramids of Gizeh in 1837, a text that still retained relevance into modern times.
Vyse collected Egyptian antiquities, some of which were gifted to the British Museum.
One item was a 12th dynasty granodiorite statue of Senwosret I (EA 44) said to be from Karnak.
Another item from his collection, also in the British Museum was a 4th dynasty wooden anthropoid coffin of Menkaure (EA 6647).
Bibliography: Who Was Who in Egyptology 4th Revised Edition. Ed. M L Bierbrier. London: The Egypt Exploration Society (2012)